For research use only. Not for therapeutic Use.
CK1-IN-3 (compound 51) is a AC1 inhibitor with an IC50s 2.22 µM for CK-1δ[1][2].
CK1-IN-3 (compound 35) (100 nM; feed) significantly extendes fly lifespan to 36.17 days[2].
| Catalog Number | I040955 |
| CAS Number | 349438-74-0 |
| Synonyms | N-(6-methoxy-1,3-benzothiazol-2-yl)-2-(2-methoxyphenyl)acetamide |
| Molecular Formula | C17H16N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C17H16N2O3S/c1-21-12-7-8-13-15(10-12)23-17(18-13)19-16(20)9-11-5-3-4-6-14(11)22-2/h3-8,10H,9H2,1-2H3,(H,18,19,20) |
| InChIKey | HFBLBLSJZDGKCC-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)N=C(S2)NC(=O)CC3=CC=CC=C3OC |
| Reference | [1]. Ana MARTÍNEZ GIL, et al. Substituted benzothiazoles and therapeutic uses thereof for the treatment of human diseases. WO2014114825A1. [2]. Salado IG, et al. Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. J Med Chem. 2014 Mar 27;57(6):2755-72. |
