CKLF1-C19

• CAT Number: I042260
• CAS Number: 960358-79-6
• Molecular Formula: C103H161N27O28
• Molecular Weight: 2225.54
• Purity: ≥95%

CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4[1].
CKLF1-C19 (200 ng/mL or 500 ng/mL; 30 min) induces chemotactic migration of human Th2 cells[1].
CKLF1-C19 (100 ng/mL; 30 min) inhibits CCL11-induced chemotaxis of mouse eosinophils and human CCR3-transfected or mouse CCR3-transfected HEK293 cells[1].
CKLF1-C19 (0.01-100 μg, 200 μL; i.p.; single dose at day 24-26, 30 min before OVA induced) results in a significant reduction of airway hyperresponsiveness (AHR) compared to ovalbumin (OVA) group with saline[1].
CKLF1-C19 (0.5 mg or 1 mg, 200 μL; s.c.; single dose) reduces CCL11-mediated recruitment of eosinophils into the peritoneal cavity in a mouse model of asthma[1].

Reference

[1]. Tian L, et al. The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4-mediated chemotaxis in a mouse model of asthma. Allergy. 2011 Feb;66(2):287-97.
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