For research use only. Not for therapeutic Use.
Cl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I045043 |
| CAS Number | 170304-76-4 |
| Synonyms | 2-[2-(2-chloroethoxy)ethoxy]acetic acid |
| Molecular Formula | C6H11ClO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H11ClO4/c7-1-2-10-3-4-11-5-6(8)9/h1-5H2,(H,8,9) |
| InChIKey | WNFWETCQRCCYKU-UHFFFAOYSA-N |
| SMILES | C(COCC(=O)O)OCCCl |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
