For research use only. Not for therapeutic Use.
Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I044715 |
| CAS Number | 158553-98-1 |
| Synonyms | 2-[2-[2-[2-(2-chloroethoxy)ethoxy]ethoxy]ethoxy]acetic acid |
| Molecular Formula | C10H19ClO6 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H19ClO6/c11-1-2-14-3-4-15-5-6-16-7-8-17-9-10(12)13/h1-9H2,(H,12,13) |
| InChIKey | XBWVBVYMGRKKOO-UHFFFAOYSA-N |
| SMILES | C(COCCOCC(=O)O)OCCOCCCl |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
