For research use only. Not for therapeutic Use.
CL656 (Cat.No:I019468) is a novel small molecule inhibitor that targets the protein kinase PIM1. PIM1 is involved in cell survival, proliferation, and tumor development. CL656 has demonstrated potent anti-proliferative activity against various cancer cell lines by inhibiting PIM1 kinase activity. Preclinical studies have shown promising results, indicating its potential as an anti-cancer therapeutic agent. Further research is underway to evaluate its efficacy and safety for clinical applications.
| Catalog Number | I019468 |
| CAS Number | 1951464-79-1 |
| Molecular Formula | C₂₀H₂₁F₂N₉O₉P₂S₂ |
| Purity | ≥95% |
| IUPAC Name | 9-[(1R,6R,8R,9R,10R,15R,17R,18R)-17-(6-aminopurin-9-yl)-9,18-difluoro-3-hydroxy-12-oxo-12-sulfanyl-3-sulfanylidene-2,4,7,11,13,16-hexaoxa-3lambda5,12lambda5-diphosphatricyclo[13.3.0.06,10]octadecan-8-yl]-1H-purin-6-one |
| InChI | InChI=1S/C20H21F2N9O9P2S2/c21-9-13-7(37-19(9)30-5-28-11-15(23)24-3-25-16(11)30)1-35-42(34,44)40-14-8(2-36-41(33,43)39-13)38-20(10(14)22)31-6-29-12-17(31)26-4-27-18(12)32/h3-10,13-14,19-20H,1-2H2,(H,33,43)(H,34,44)(H2,23,24,25)(H,26,27,32)/t7-,8-,9-,10-,13-,14-,19-,20-,41?,42?/m1/s1 |
| InChIKey | WBEHEZDHRLNQIK-IRYAPSAPSA-N |
| SMILES | C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=CNC4=O)F)OP(=O)(OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C=NC7=C(N=CN=C76)N)F)OP(=S)(O1)O)S |
| Reference | [1]. Lioux T, et al. Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING). J Med Chem. 2016 Nov 23;59(22):10253-10267. |
