Clathrin-IN-4

• CAT Number: I042277
• CAS Number: 762242-59-1
• Molecular Formula: C17H18Br2N2O
• Molecular Weight: 426.15
• Purity: ≥95%
• Synonyms: (2R)-1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol
• InChI: InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3/t13-/m1/s1
• InChIKey: XUBJEDZHBUPBKL-CYBMUJFWSA-N
• SMILES: CN(C)C[C@H](CN1C2=C(C=C(C=C2)Br)C3=C1C=CC(=C3)Br)O

Clathrin-IN-4（Cat No.:I042277）is a small molecule inhibitor designed to target clathrin, a protein involved in clathrin-mediated endocytosis, a process that regulates cellular uptake of molecules. By inhibiting clathrin, Clathrin-IN-4 can potentially disrupt the internalization of receptors and cargo into cells, affecting various cellular functions such as signaling, nutrient uptake, and intracellular trafficking. This inhibitor is being studied for its potential therapeutic applications in cancer and other diseases where clathrin-mediated endocytosis plays a critical role. It may provide a novel approach for manipulating cellular processes to treat certain conditions.

Reference

[1]. Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.
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