For research use only. Not for therapeutic Use.
Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM[1].
| Catalog Number | I042277 |
| CAS Number | 762242-59-1 |
| Synonyms | (2R)-1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol |
| Molecular Formula | C17H18Br2N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3/t13-/m1/s1 |
| InChIKey | XUBJEDZHBUPBKL-CYBMUJFWSA-N |
| SMILES | CN(C)CC(CN1C2=C(C=C(C=C2)Br)C3=C1C=CC(=C3)Br)O |
| Reference | [1]. Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001. |
