For research use only. Not for therapeutic Use.
Clemizole HCl（Cat No.:I004937）is an antihistamine primarily used to treat allergic conditions by blocking histamine H1 receptors, providing relief from symptoms such as itching, sneezing, and hives. In addition to its antihistaminic effects, Clemizole has shown potential in research for its antiviral and anti-inflammatory properties. It has been studied for its ability to inhibit hepatitis C virus replication and is being explored for other therapeutic applications, including treating neurological conditions like Dravet syndrome. Its diverse pharmacological profile makes it an intriguing compound in both clinical and research settings.
| Catalog Number | I004937 |
| CAS Number | 1163-36-6 (HCl) |
| Synonyms | AL 20; AL20; AL-20; P 48; Reactrol; Clemizole.;1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole hydrochloride |
| Molecular Formula | C19H21Cl2N3 |
| Purity | ≥95% |
| Target | TRPC5 inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;hydrochloride |
| InChI | InChI=1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H |
| InChIKey | DNFMJYXRIMLMBZ-UHFFFAOYSA-N |
| SMILES | C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl.Cl |
| Reference | </br>1: Richter JM, Schaefer M, Hill K. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. doi: 10.1124/mol.114.093229. Epub 2014 Aug 19. PubMed PMID: 25140002.</br |
