Clemizole

• CAT Number: I003565
• CAS Number: 442-52-4
• Molecular Formula: C19H20ClN3
• Molecular Weight: 325.84
• Purity: ≥95%
• Synonyms: 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 8 mM (NS4B)
• InChI: InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2
• InChIKey: CJXAEXPPLWQRFR-UHFFFAOYSA-N
• SMILES: C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl

Clemizole（Cat No.:I003565）is an antihistamine with sedative properties, primarily used in the treatment of allergic conditions, such as hay fever and allergic rhinitis. It acts as a selective H1 receptor antagonist, blocking the effects of histamine, which alleviates symptoms like sneezing, itching, and runny nose. Additionally, clemizole has been investigated for its potential neuroprotective effects and as an adjunct in managing certain neurological disorders. While it provides effective relief from allergy symptoms, its sedative effects can limit its use, as it may cause drowsiness in some individuals. Monitoring is recommended during treatment.

Reference

[1]. Einav S, Sobol HD, Gehrig E, The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74.
[2]. Nishimura T, Hu Y, Wu M, Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.
[3]. Martínez-Mir I, Herrero J, Esta? L, Effect of histamine on the longitudinal and circular muscle of the oestrogen dominated rat uterus. Agents Actions. 1993 May;39(1-2):1-5.