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38083-17-9-Climbazole Climbazole

Climbazole

For research use only. Not for therapeutic Use.

  • CAT Number: A000681
  • CAS Number: 38083-17-9
  • Molecular Formula: C15H17ClN2O2
  • Molecular Weight: 292.76
  • Purity: ≥95%
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Related Small Molecules: Mosapride Citrate     FILIPIN COMPLEX     Edoxaban    

Climbazole（Cat No.:A000681）is an antifungal agent commonly used in dermatological applications to treat fungal infections, including dandruff, seborrheic dermatitis, and athlete’s foot. It works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes, thereby disrupting cell membrane integrity and preventing fungal growth. Its broad-spectrum antifungal properties make it an effective treatment against a variety of dermatophytes and yeasts. Climbazole is widely incorporated into topical formulations, such as shampoos, creams, and lotions, due to its mildness and high efficacy in controlling fungal infections.


Catalog Number A000681
CAS Number 38083-17-9
Synonyms

38083-17-9; Baypival; Climbazol; Baysan

Molecular Formula C15H17ClN2O2
Purity ≥95%
Target Fungal
Storage -20°C
IUPAC Name 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
InChI InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
InChIKey OWEGWHBOCFMBLP-UHFFFAOYSA-N
SMILES CC(C)(C)C(=O)C(N1C=CN=C1)OC2=CC=C(C=C2)Cl
Reference

1: Hawkins S, Adamus J, Chiang CY, Covell E, O/’Leary J, Lee JM. Retinyl
propionate and climbazole combination demonstrates clinical improvement to the
appearance of hyperpigmentation and deep wrinkling with minimal irritation. Int J
Cosmet Sci. 2017 Dec;39(6):589-599. doi: 10.1111/ics.12412. Epub 2017 Sep 21.
PubMed PMID: 28733999.
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2: Chen G, Ji C, Miao M, Yang K, Luo Y, Hoptroff M, Collins LZ, Janssen HG.
Ex-vivo measurement of scalp follicular infundibulum delivery of zinc pyrithione
and climbazole from an anti-dandruff shampoo. J Pharm Biomed Anal. 2017 Sep
5;143:26-31. doi: 10.1016/j.jpba.2017.05.031. Epub 2017 May 17. PubMed PMID:
28550716.
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3: Brienza M, Chiron S. Enantioselective reductive transformation of climbazole:
A concept towards quantitative biodegradation assessment in anaerobic biological
treatment processes. Water Res. 2017 Jun 1;116:203-210. doi:
10.1016/j.watres.2017.03.037. Epub 2017 Mar 21. PubMed PMID: 28340418.

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4: Adamus J, Feng L, Hawkins S, Kalleberg K, Lee JM. Climbazole boosts activity
of retinoids in skin. Int J Cosmet Sci. 2017 Aug;39(4):411-418. doi:
10.1111/ics.12390. Epub 2017 Mar 2. PubMed PMID: 28103388.
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5: Youn HJ, Kim SY, Park M, Jung WH, Lee YW, Choe YB, Ahn KJ. Efficacy and Safety
of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic
Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study. Ann Dermatol.
2016 Dec;28(6):733-739. Epub 2016 Nov 23. PubMed PMID: 27904273; PubMed Central
PMCID: PMC5125955.
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6: Liu WR, Ying GG, Zhao JL, Liu YS, Hu LX, Yao L, Liang YQ, Tian F.
Photodegradation of the azole fungicide climbazole by ultraviolet irradiation
under different conditions: Kinetics, mechanism and toxicity evaluation. J Hazard
Mater. 2016 Nov 15;318:794-801. doi: 10.1016/j.jhazmat.2016.06.033. Epub 2016 Jun
16. PubMed PMID: 27378240.

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7: Fabbrocini G, Panariello L, DE Padova MP, Lorenzi S, Caro G, Marasca C, Russo
G. Efficacy and tolerability of a spray product containing hydroxypropyl
chitosan, climbazole and piroctone olamine, applied twice weekly for the
treatment of the pitiriasis versicolor. G Ital Dermatol Venereol. 2017
Dec;152(6):565-568. doi: 10.23736/S0392-0488.16.05299-8. Epub 2016 Jul 5. PubMed
PMID: 27377141.

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8: Petit JY, Cavana P, Thoumire S, Guillot J, Perrot S. Use of a modified hair
strand test to assess the antifungal activity kinetics of dog hair after a 2%
climbazole shampoo application. Vet Dermatol. 2016 Jun;27(3):148-e38. doi:
10.1111/vde.12304. Epub 2016 Apr 12. PubMed PMID: 27072515.

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9: Moriello KA. In vitro efficacy of shampoos containing miconazole,
ketoconazole, climbazole or accelerated hydrogen peroxide against Microsporum
canis and Trichophyton species. J Feline Med Surg. 2017 Apr;19(4):370-374. doi:
10.1177/1098612X15626197. Epub 2016 Jul 9. PubMed PMID: 26809882.

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10: Cavana P, Petit JY, Perrot S, Guechi R, Marignac G, Reynaud K, Guillot J.
Efficacy of a 2% climbazole shampoo for reducing Malassezia population sizes on
the skin of naturally infected dogs. J Mycol Med. 2015 Dec;25(4):268-73. doi:
10.1016/j.mycmed.2015.10.004. Epub 2015 Nov 18. PubMed PMID: 26603053.

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