Clindamycin B-d3 2-Phosphate

• CAT Number: R048475
• CAS Number: NA
• Molecular Formula: C₁₇H₂₉D₃ClN₂O₈PS
• Molecular Weight: 493.95
• Purity: ≥95%
• Synonyms: Methyl 7-Chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-1-(methyl-d3)-2-pyrrolidinyl]?carbonyl]amino]-1-thio-L-threo-α-D-galactooctopyranoside 2-(Dihydrogen Phosphate); (2S-trans)-Methyl 7-Chloro-6,7,8-trideoxy-6-[[(4-ethyl-1-(methyl-d3)-2-pyrrolidinyl)?
• Storage: -20°C
• IUPAC Name: [(2R,5R,6R)-6-[(1S,2S)-2-chloro-1-[[(4R)-4-ethyl-1-(trideuteriomethyl)pyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate
• InChI: InChI=1S/C17H32ClN2O8PS/c1-5-9-6-10(20(3)7-9)16(23)19-11(8(2)18)14-12(21)13(22)15(17(27-14)30-4)28-29(24,25)26/h8-15,17,21-22H,5-7H2,1-4H3,(H,19,23)(H2,24,25,26)/t8-,9+,10?,11+,12+,13?,14+,15?,17+/m0/s1/i3D3
• InChIKey: GOTDPKVMVWZIIW-BHOIPQKFSA-N
• SMILES: [2H]C([2H])([2H])N1C[C@@H](CC1C(=O)N[C@@H]([C@@H]2[C@@H](C(C([C@H](O2)SC)OP(=O)(O)O)O)O)[C@H](C)Cl)CC

Clindamycin B-d3 2-Phosphate is a deuterated analog of Clindamycin B 2-phosphate, an active metabolite of the antibiotic clindamycin. In this compound, three hydrogen atoms are replaced with deuterium, specifically enhancing its stability and allowing for precise tracking in pharmacokinetic and metabolic studies. The phosphate ester form is important for the compound’s solubility and bioavailability in biological systems. Clindamycin B-d3 2-Phosphate is essential in research focused on the absorption, distribution, metabolism, and excretion (ADME) of clindamycin, particularly in studying the drug’s interaction with bacterial ribosomes and its role in inhibiting protein synthesis. This isotopically labeled compound provides reliable data for optimizing clindamycin’s therapeutic efficacy and safety in antibiotic development.