Clindamycin hydrochloride monohydrate

• CAT Number: I018203
• CAS Number: 58207-19-5
• Molecular Formula: C₁₈H₃₆Cl₂N₂O₆S
• Molecular Weight: 479.46
• Purity: ≥95%
• Target: Bacterial
• IUPAC Name: (2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrate;hydrochloride
• InChI: InChI=1S/C18H33ClN2O5S.ClH.H2O/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H;1H2/t9-,10+,11-,12+,13-,14+,15+,16+,18+;;/m0../s1
• InChIKey: KWMXKEGEOADCEQ-WNNJHRBUSA-N
• SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl.O.Cl

Clindamycin Hydrochloride Monohydrate（Cat No.:I018203）is a lincosamide antibiotic used to treat a variety of bacterial infections, particularly those caused by anaerobes and some Gram-positive bacteria, including Staphylococcus aureus and Streptococcus species. It works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, which halts bacterial growth. Clindamycin is commonly prescribed for respiratory, skin, and soft tissue infections, as well as certain dental infections. The monohydrate form improves its solubility, enhancing absorption and bioavailability. Its efficacy against anaerobes makes it valuable in managing complex infections.

Reference

[1]. Hodille E, et al. Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17(1):38.