CLK1-IN-1

• CAT Number: I019959
• CAS Number: 2123491-32-5
• Molecular Formula: C₂₄H₁₆FN₅O
• Molecular Weight: 409.42
• Purity: ≥95%
• IUPAC Name: 5-[1-[(1S)-1-(4-fluorophenyl)ethyl]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole
• InChI: InChI=1S/C24H16FN5O/c1-14(15-2-6-18(25)7-3-15)30-24-19-10-16(4-8-20(19)26-12-22(24)28-29-30)17-5-9-23-21(11-17)27-13-31-23/h2-14H,1H3/t14-/m0/s1
• InChIKey: BHKVSOQUPYXVRZ-AWEZNQCLSA-N
• SMILES: C[C@@H](C1=CC=C(C=C1)F)N2C3=C4C=C(C=CC4=NC=C3N=N2)C5=CC6=C(C=C5)OC=N6

CLK1-IN-1（Cat No.:I019959）is a selective inhibitor of the CDC-like kinase 1 (CLK1), an enzyme involved in pre-mRNA splicing regulation by phosphorylating serine/arginine-rich proteins. By inhibiting CLK1, CLK1-IN-1 disrupts alternative splicing processes, making it a valuable tool for studying RNA splicing mechanisms and their role in various diseases, including cancer and neurodegenerative disorders. Its selectivity for CLK1 offers potential therapeutic applications in targeting diseases associated with abnormal splicing patterns. CLK1-IN-1 is widely used in biomedical research to explore novel drug development strategies.

Reference

[1]. Sun QZ, et al. Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. J Med Chem. 2017 Jul 27;60(14):6337-6352.