Clobetasol Propionate-d5

• CAT Number: I024927
• CAS Number: 2280940-18-1
• Molecular Formula: C25H27D5ClFO5
• Molecular Weight: 472.0049
• Purity: 98%
• Synonyms: Clobetasol Propionate-d5; Clobetasol Propionate d5; CCI-4725-d5; CCI4725-d5; CCI 4725-d5; CGP 9555-d5; CGP9555-d5; CGP-9555-d5; Clobetasol 17-propionate-d5; Clobetasol 17 propionate-d5
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propanoate-d5
• InChI: InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1/i1D3,5D2
• InChIKey: CBGUOGMQLZIXBE-BFHSNLKKSA-N
• SMILES: O=C1C=C[C@]2(C(CC[C@@]3([C@@]2([C@H](C[C@]4([C@]3(C[C@@H]([C@]4(OC(C([2H])(C([2H])([2H])[2H])[2H])=O)C(CCl)=O)C)[H])C)O)F)[H])=C1)C

Clobetasol propionate-d5 is a deuterated form of clobetasol propionate, with five hydrogen atoms replaced by deuterium. This compound is used primarily in pharmacokinetic and metabolic studies to precisely track and analyze the drug’s behavior in biological systems through mass spectrometry and NMR spectroscopy. Clobetasol propionate is a potent corticosteroid used in dermatology to treat various inflammatory skin conditions. The deuterium labeling allows researchers to study the drug’s absorption, distribution, metabolism, and excretion in detail, providing insights into its efficacy and safety profiles without altering its pharmacological activity.