Clobetasone 17-Butyrate

• CAT Number: R050875
• CAS Number: 25122-57-0
• Molecular Formula: C26H32ClFO5
• Molecular Weight: 478.98
• Purity: ≥95%
• Synonyms: (16β)-21-Chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)pregna-1,4-diene-3,11,20-trione;?CCl 5537; Clobetasone 17-Butyrate; Emovate; Eumovate; GR 2/1214; Kindavate; Molivate; SN 203
• Target: Vitamin D Related/Nuclear Receptor
• Storage: Store at -20°C
• IUPAC Name: [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate
• InChI: InChI=1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1
• InChIKey: FBRAWBYQGRLCEK-AVVSTMBFSA-N
• SMILES: CCCC(=O)OC1(C(CC2C1(CC(=O)C3(C2CCC4=CC(=O)C=CC43C)F)C)C)C(=O)CCl

Clobetasone 17-butyrate (Cat No.:R050875) is a synthetic corticosteroid that serves as a topical anti-inflammatory and anti-pruritic agent. It is used in various dermatological preparations, such as creams, ointments, and lotions, to treat skin conditions like eczema, psoriasis, and allergic reactions. As a glucocorticoid receptor agonist, it helps to suppress inflammation, reduce itching, and alleviate redness associated with these skin disorders. The butyrate ester modification enhances its skin penetration and effectiveness.