Clofilium phosphate

• CAT Number: I024957
• CAS Number: 68379-03-3
• Molecular Formula: C21H37ClNO4P2-
• Molecular Weight: 433.95
• Purity: 98%
• Synonyms: Clofilium phosphate
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4-(4-chlorophenyl)butyl-diethyl-heptylazanium;dihydrogen phosphate
• InChI: InChI=1S/C21H37ClN.H3O4P/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20;1-5(2,3)4/h14-17H,4-13,18-19H2,1-3H3;(H3,1,2,3,4)/q+1;/p-3
• InChIKey: HBLQZEWZVJXHKQ-UHFFFAOYSA-K
• SMILES: CCCCCCC[N+](CC)(CC)CCCCC1=CC=C(Cl)C=C1.O=P([O-])([O-])[O-]

Clofilium phosphate(CAT: I024957) is a class III antiarrhythmic agent that acts as a potassium channel blocker, specifically targeting delayed rectifier potassium currents (IKr). By inhibiting these channels, it prolongs the action potential duration and the effective refractory period in cardiac tissues, helping to regulate abnormal heart rhythms. Clofilium phosphate is widely used in cardiac electrophysiology research for studying potassium channel dynamics, arrhythmogenesis, and the development of antiarrhythmic therapies. Its mechanism of action provides valuable insights into the role of ion channels in cardiac excitability and rhythm control, supporting advancements in the treatment of cardiac arrhythmias.