Clofilium tosylate

• CAT Number: I019516
• CAS Number: 92953-10-1
• Molecular Formula: C₂₈H₄₄ClNO₃S
• Molecular Weight: 510.17
• Purity: ≥95%

Clofilium tosylate (CAT: I019516) is a potassium channel blocker primarily used as an antiarrhythmic agent. It selectively inhibits the rapid component of the delayed rectifier potassium current (IKr) in cardiac cells, prolonging the cardiac action potential duration. By blocking these potassium channels, Clofilium tosylate helps stabilize the electrical activity of the heart and can be effective in treating certain types of cardiac arrhythmias, including atrial fibrillation. However, due to its potential proarrhythmic effects, its use is restricted and requires careful monitoring. Clofilium tosylate has also been studied for its potential anticancer properties and has shown inhibitory effects on tumor cell growth and migration.

Reference

[1]. Choi BY, et al. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Lett. 1999 Dec 1;147(1-2):85-93.