Clofoctol

• CAT Number: I003385
• CAS Number: 37693-01-9
• Molecular Formula: C21H26Cl2O
• Molecular Weight: 365.34
• Purity: ≥95%
• Synonyms: Octofene; Clofoctol [INN]
• Target: Bacterial; SARS-CoV; Antibiotic
• Solubility: DMSO: ≥ 3.7 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
• InChI: InChI=1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3
• InChIKey: HQVZOORKDNCGCK-UHFFFAOYSA-N
• SMILES: CC(C)(C)CC(C)(C)C1=CC(=C(C=C1)O)CC2=C(C=C(C=C2)Cl)Cl

Clofoctol（Cat No.:I003385）is an antibiotic compound used primarily in the treatment of respiratory tract infections caused by Gram-positive bacteria, including Streptococcus pneumoniae and Staphylococcus aureus. It works by inhibiting bacterial protein synthesis, thus preventing bacterial growth. Clofoctol has demonstrated efficacy in managing infections such as pneumonia and bronchitis. Its broad-spectrum activity, coupled with relatively low resistance development, makes it a valuable option for combating bacterial infections in clinical settings. Although it is less commonly prescribed today, it remains a notable example of a semi-synthetic antibiotic with targeted antibacterial effects.

Reference

1.Fan, Lixia, et al. "Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways." Cancer management and research 10 (2018): 4817.
2.Wang, Minghua, et al. "Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer." British journal of pharmacology 171.19 (2014): 4478-4489.