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22199-46-8-Clomacran phosphate Clomacran phosphate

Clomacran phosphate

For research use only. Not for therapeutic Use.

  • CAT Number: I024962
  • CAS Number: 22199-46-8
  • Molecular Formula: C18H24ClN2O4P
  • Molecular Weight: 398.82
  • Purity: 98%
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Related Small Molecules: GRP-60367 hydrochloride     CU-CPT17e     TP0427736 hydrochloride    

Clomacran phosphate is an Antipsychotic


Catalog Number I024962
CAS Number 22199-46-8
Synonyms

Clomacran phosphate; SKF14336; SKF-14336; SKF 14336

Molecular Formula C18H24ClN2O4P
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 9-Acridinepropanamine, 2-chloro-9,10-dihydro-N,N-dimethyl-, phosphate (1:1)
InChI InChI=1S/C18H21ClN2.H3O4P/c1-21(2)11-5-7-14-15-6-3-4-8-17(15)20-18-10-9-13(19)12-16(14)18;1-5(2,3)4/h3-4,6,8-10,12,14,20H,5,7,11H2,1-2H3;(H3,1,2,3,4)
InChIKey SKKDWRIEPIZVOR-UHFFFAOYSA-N
SMILES CN(C)CCCC1C2=C(C=CC=C2)NC3=CC=C(Cl)C=C13.O=P(O)(O)O
Reference

1: Simpson GM. Clomacran-Phosphat gegen chronische Schizophrenie [Clomacran- phosphate against schizophrenia]. Munch Med Wochenschr. 1970 Oct 16;42:3. German. PMID: 5536267.
2: Pecknold JC, Ban TA, Lehmann HE, Climan M. Clomacran in the treatment of schizophrenic patients: a comparison of two assessment methods. Int J Clin Pharmacol Biopharm. 1975 Jun;11(4):299-303. PMID: 1099021.
3: Irwin GM, Dodson GJ, Ravin LJ. Encapsulation of clomacran phosphate [2-chloro-9[3-(dimethylamino) propyl]acridan phosphate] I. Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredient on weight variation of capsules filled on an automatic capsule-filling machine. J Pharm Sci. 1970 Apr;59(4):547-50. doi: 10.1002/jps.2600590423. PMID: 5440686.
4: Lampe WT 2nd. Adverse effects with clomacran. J Clin Pharmacol J New Drugs. 1970 May-Jun;10(3):171-4. PMID: 5266631.
5: Samara MT, Cao H, Helfer B, Davis JM, Leucht S. Chlorpromazine versus every other antipsychotic for schizophrenia: a systematic review and meta-analysis challenging the dogma of equal efficacy of antipsychotic drugs. Eur Neuropsychopharmacol. 2014 Jul;24(7):1046-55. doi: 10.1016/j.euroneuro.2014.03.012. Epub 2014 Apr 4. PMID: 24766970.
6: Lampe WT 2nd. A double blind study of clomacran. Curr Ther Res Clin Exp. 1969 May;11(5):300-6. PMID: 4977403.
7: Rickels K, Perloff M, Perez LA, Pereira-Ogan JA, Kelly EA, Hesbacher PT. Clomacran in anxious neurotic outpatients: a controlled study. J Clin Pharmacol New Drugs. 1972 Jan;12(1):46-53. doi: 10.1002/j.1552-4604.1972.tb00035.x. PMID: 4550225.
8: Edwards JG, Simpson GM. A trial of clomacran phosphate (SK&F 14,336) in mania. Curr Ther Res Clin Exp. 1969 Mar;11(3):115-7. PMID: 4976239.
9: Nair KC, Chen CH. Clinical trial of clomacran phosphate (SKF-14336) in chronic psychotic male patients. Curr Ther Res Clin Exp. 1970 Jun;12(6):394-401. PMID: 4987347.
10: Fowler PJ, Zirkle CL, Macko E, Kaiser C, Sarau H, Tedeschi DH. Pharmacological evaluation of clomacran, a new potent psychotropic agent. Arzneimittelforschung. 1977;27(4):866-72. PMID: 17419.

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