Clomipramine

• CAT Number: I024968
• CAS Number: 303-49-1
• Molecular Formula: C19H23ClN2
• Molecular Weight: 314.86
• Purity: ≥95%
• Synonyms: Clomipramine, Anafranil (free base), Anafranil, Chlorimipramine, Clomicalm, Clomipramina, Clomipraminum, Monochlorimipramine, HSDB 7746
• Target: Serotonin Transporter
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: 5H-Dibenz(b,f)azepine, 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-
• InChI: 1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
• InChIKey: GDLIGKIOYRNHDA-UHFFFAOYSA-N
• SMILES: N1(CCCN(C)C)c2c(CCc3ccccc13)ccc(c2)Cl

Clomipramine (Cat.No:I024968) is a tricyclic antidepressant medication. It is primarily used for the treatment of obsessive-compulsive disorder (OCD) and major depressive disorder. Clomipramine works by increasing the levels of certain chemicals in the brain, such as serotonin, which helps regulate mood and behavior. It is available in oral form and should be taken under the supervision of a healthcare professional.

Reference

1: Yildirim EA, Hacioglu Yildirim M, Carpar E, Sarac I. Clomipramine trial for treatment-resistant persistent genital arousal disorder: a case series. J Psychosom Obstet Gynaecol. 2017 Dec;38(4):260-267. doi: 10.1080/0167482X.2017.1296427. Epub 2017 Mar 3. PubMed PMID: 28635538.
2: Brown JT, Schneiderhan M, Eum S, Bishop JR. Serum clomipramine and desmethylclomipramine levels in a CYP2C19 and CYP2D6 intermediate metabolizer. Pharmacogenomics. 2017 May;18(7):601-605. doi: 10.2217/pgs-2017-0015. Epub 2017 May 4. Review. PubMed PMID: 28470111.
3: Hatalova H, Radostova D, Pistikova A, Vales K, Stuchlik A. Detrimental effect of clomipramine on hippocampus-dependent learning in an animal model of obsessive-compulsive disorder induced by sensitization with d2/d3 agonist quinpirole. Behav Brain Res. 2017 Jan 15;317:210-217. doi: 10.1016/j.bbr.2016.09.042. Epub 2016 Sep 19. PubMed PMID: 27659555.
4: Varigonda AL, Jakubovski E, Bloch MH. Systematic Review and Meta-Analysis: Early Treatment Responses of Selective Serotonin Reuptake Inhibitors and Clomipramine in Pediatric Obsessive-Compulsive Disorder. J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):851-859.e2. doi: 10.1016/j.jaac.2016.07.768. Epub 2016 Aug 4. Review. PubMed PMID: 27663940.
5: Gellén B, Völgyi K, Györffy BA, Darula Z, Hunyadi-Gulyás É, Baracskay P, Czurkó A, Hernádi I, Juhász G, Dobolyi Á, Kékesi KA. Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression. J Proteomics. 2017 Feb 5;153:53-64. doi: 10.1016/j.jprot.2016.06.027. Epub 2016 Jun 29. PubMed PMID: 27371348.
6: Ter Horst PG, Proost JH, Smit JP, Vries MT, de Jong-van de Berg LT, Wilffert B. Pharmacokinetics of clomipramine during pregnancy. Eur J Clin Pharmacol. 2015 Dec;71(12):1493-500. doi: 10.1007/s00228-015-1944-6. Epub 2015 Sep 29. PubMed PMID: 26416100.
7: Karameh WK, Khani M. Intravenous Clomipramine for Treatment-Resistant Obsessive-Compulsive Disorder. Int J Neuropsychopharmacol. 2015 Jul 28;19(2). pii: pyv084. doi: 10.1093/ijnp/pyv084. PubMed PMID: 26221004; PubMed Central PMCID: PMC4772819.
8: Marcourakis T, Bernik MA, Lotufo Neto F, Gedanke Shavitt R, Gorenstein C. Clomipramine demethylation rate is important on the outcome of obsessive-compulsive disorder treatment. Int Clin Psychopharmacol. 2015 Jan;30(1):43-8. doi: 10.1097/YIC.0000000000000050. PubMed PMID: 25279584.