For research use only. Not for therapeutic Use.
Cloperastine benzoate （Cat No.:I013128） is a compound that exhibits concentration-dependent inhibition of hERG (human ether-à-go-go-related gene) potassium currents. It achieves this by blocking the activity of hERG channels, with an IC50 value of 27 nM. The hERG channel plays a crucial role in cardiac repolarization, and its inhibition can lead to adverse effects on cardiac function, such as QT interval prolongation.
| Catalog Number | I013128 |
| CAS Number | 85187-37-7 |
| Molecular Formula | C₄₀H₃₈ClNO₅ |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | -20°C |
| IUPAC Name | 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine;2-(4-hydroxy-3-phenylbenzoyl)benzoic acid |
| InChI | InChI=1S/C20H24ClNO.C20H14O4/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;21-18-11-10-14(12-17(18)13-6-2-1-3-7-13)19(22)15-8-4-5-9-16(15)20(23)24/h1,3-4,7-12,20H,2,5-6,13-16H2;1-12,21H,(H,23,24) |
| InChIKey | PXZFKAKWSHBDCP-UHFFFAOYSA-N |
| SMILES | C1CCN(CC1)CCOC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.C1=CC=C(C=C1)C2=C(C=CC(=C2)C(=O)C3=CC=CC=C3C(=O)O)O |
| Reference | [1]. Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120(3):165-75.<br>[2]. Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment of cough. Ther Clin Risk Manag. 2011;7:83-92. |
