For research use only. Not for therapeutic Use.
(+)-<wbr></wbr>Cloprostenol is a synthetic analog of prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-<wbr></wbr>Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF<sub>2α</sub> in terminating pregnancy when given subcutaneously at a daily dose of 0.125 μg/kg in rats and hamsters, without the side effects associated with PGF<sub>2α</sub>. (+)-<wbr></wbr>Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC<sub>50</sub> value of 3 x 10-<wbr></wbr>12 M.
| Catalog Number | R065329 |
| CAS Number | 54276-21-0 |
| Synonyms | D-Cloprostenol;(+)-16-m-chlorophenoxy tetranor PGF2α;(+)-16-m-chlorophenoxy tetranor Prostaglandin F2α |
| Molecular Formula | C22H29ClO6 |
| Purity | ≥95% |
| Target | Prostaglandin Receptor |
| Storage | -20°C |
| IUPAC Name | (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid |
| InChI | InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1 |
| InChIKey | VJGGHXVGBSZVMZ-QIZQQNKQSA-N |
| SMILES | C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O |
| Reference | 1.Dukes, M.,Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α. Nature 250, 330-331 (1974). |
