Cloricromen HCl

• CAT Number: I024986
• CAS Number: 74697-28-2
• Molecular Formula: C20H27Cl2NO5
• Molecular Weight: 432.34
• Purity: 98%
• Synonyms: Cloricromen HCl; Cloricromen hydrochloride
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: ethyl 2-((8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetate hydrochloride
• InChI: InChI=1S/C20H26ClNO5.ClH/c1-5-22(6-2)11-10-15-13(4)14-8-9-16(26-12-17(23)25-7-3)18(21)19(14)27-20(15)24;/h8-9H,5-7,10-12H2,1-4H3;1H
• InChIKey: CCCZJRFQJNGCCU-UHFFFAOYSA-N
• SMILES: CCOC(COc1c(Cl)c2c(C(C)=C(C(O2)=O)CCN(CC)CC)cc1)=O.Cl

Cloricromen HCl is the salt form of Cloricromen, a platelet aggregation inhibitor.

Reference

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2: Ianaro A, Maffia P, Grassia G, Di Meglio P, Sorrentino R, di Villa Bianca Rd, Di Rosa M, Ialenti A. Cloricromene in endotoxemia: role of NF-kappaB. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):140-5. doi: 10.1007/s00210-004-0956-z. Epub 2004 Jul 30. PMID: 15322736.
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7: Pignatello R, Ricupero N, Bucolo C, Maugeri F, Maltese A, Puglisi G. Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene. AAPS PharmSciTech. 2006 Mar 24;7(1):E27. doi: 10.1208/pt070127. PMID: 16584158; PMCID: PMC2750734.
8: Ragazzi E, Costa CV, Comai S, Bertazzo A, Caparrotta L, Allegri G. Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits. Life Sci. 2006 Jan 18;78(8):785-94. doi: 10.1016/j.lfs.2005.05.077. Epub 2005 Aug 26. PMID: 16126232.
9: Maltese A, Bucolo C. Simultaneous determination of cloricromene and its active metabolite in rabbit aqueous humor by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Feb 5;767(1):153-8. doi: 10.1016/s1570-0232(01)00567-0. PMID: 11863286.
10: Corsini E, Lucchi L, Binaglia M, Viviani B, Bevilacqua C, Monastra G, Marinovich M, Galli CL. Cloricromene, a semi-synthetic coumarin derivative, inhibits tumor necrosis factor-alpha production at a pre-transcriptional level. Eur J Pharmacol. 2001 Apr 27;418(3):231-7. doi: 10.1016/s0014-2999(01)00910-4. PMID: 11343695.