Clorobiocin

• CAT Number: I012708
• CAS Number: 39868-96-7
• Molecular Formula: C35H37ClN2O11
• Molecular Weight: 697.13
• Purity: ≥95%
• Synonyms: (3S,4R,5R,6S)-6-[(8-chloro-4-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzene]amido}-2- oxo-2H-chromen-7-yl)oxy]-5-hydroxy-3-methoxy-2,2-dimethyloxan-4-yl 5-methylpyrrole- 2-carboxylate; N
• IUPAC Name: [(3R,4S,5R,6S)-6-[8-chloro-4-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-2-oxochromen-7-yl]oxy-5-hydroxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate
• InChI: InChI=1S/C35H37ClN2O11/c1-16(2)7-9-18-15-19(10-13-22(18)39)31(42)38-25-26(40)20-11-14-23(24(36)28(20)47-33(25)44)46-34-27(41)29(30(45-6)35(4,5)49-34)48-32(43)21-12-8-17(3)37-21/h7-8,10-15,27,29-30,34,37,39-41H,9H2,1-6H3,(H,38,42)/t27-,29+,30-,34-/m1/s1
• InChIKey: FJAQNRBDVKIIKK-LFLQOBSNSA-N
• SMILES: CC1=CC=C(N1)C(=O)O[C@H]2[C@H]([C@@H](OC([C@@H]2OC)(C)C)OC3=C(C4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CC(=C(C=C5)O)CC=C(C)C)O)Cl)O

Clorobiocin（Cat No.:I012708）is an aminocoumarin antibiotic known for its potent activity against gram-positive bacteria. It works by inhibiting bacterial DNA gyrase, an essential enzyme for DNA replication and transcription, thereby halting bacterial cell growth and proliferation. Clorobiocin is structurally related to other coumarin antibiotics, such as novobiocin, but has enhanced effectiveness due to chlorine substitution, which increases its binding affinity to DNA gyrase. Primarily used in research, clorobiocin is valuable for studying bacterial replication mechanisms and exploring new antibiotic targets to address drug-resistant bacterial infections.