Clorsulon

• CAT Number: A000962
• CAS Number: 60200-06-8
• Molecular Formula: C8H8Cl3N3O4S2
• Molecular Weight: 380.66
• Purity: ≥95%
• Synonyms: 60200-06-8; Curatrem; MK-401
• Storage: -20°C
• InChI: 1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)
• InChIKey: QOVTVIYTBRHADL-UHFFFAOYSA-N
• SMILES: C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl

Clorsulon is antihelminthic compound that is a potent fasciolicide.

Reference

1: Saad AS, Ismail NS, Soliman M, Zaazaa HE. Validated Stability-Indicating
RP-HPLC Method for Simultaneous Determination of Clorsulon and Ivermectin
Employing Plackett-Burman Experimental Design for Robustness Testing. J AOAC Int.
2016 Mar-Apr;99(2):571-8. doi: 10.5740/jaoacint.15-0128. Epub 2016 Mar 18. PubMed
PMID: 26997479.

2: Martínez-Valladares M, Cordero-Pérez C, Rojo-Vázquez FA. Efficacy of an
anthelmintic combination in sheep infected with Fasciola hepatica resistant to
albendazole and clorsulon. Exp Parasitol. 2014 Jan;136:59-62. doi:
10.1016/j.exppara.2013.10.010. Epub 2013 Nov 6. PubMed PMID: 24211419.

3: Kang YP, Yu J, Huh Y, Oh JH, Kwon CH, Lee SJ, Ee JW, Kim GT, Lee JG, Lee J,
Park JH, Kim YS, Kwon SW. Development of high performance liquid
chromatography-ultraviolet detection method for screening mebendazole, clorsulon,
diaveridine, and tolfenamic acid in animal-based food samples. Drug Test Anal.
2014 Mar;6(3):246-56. doi: 10.1002/dta.1467. Epub 2013 Apr 10. PubMed PMID:
23576386.

4: Richter D, Richter J, Grüner B, Kranz K, Franz J, Kern P. In vitro efficacy of
triclabendazole and clorsulon against the larval stage of Echinococcus
multilocularis. Parasitol Res. 2013 Apr;112(4):1655-60. doi:
10.1007/s00436-013-3321-7. Epub 2013 Feb 28. PubMed PMID: 23455934.

5: Hutchinson GW, Dawson K, Fitzgibbon CC, Martin PJ. Efficacy of an injectable
combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature
Fasciola hepatica compared to triclabendazole combination flukicides given orally
or topically to cattle. Vet Parasitol. 2009 Jun 10;162(3-4):278-84. doi:
10.1016/j.vetpar.2009.03.032. Epub 2009 Mar 27. PubMed PMID: 19375232.

6: Mossallam SF, Ali SM, El Zawawy LA, Said DE. The efficacy of antihelminthic
compound; Clorsulon against experimental Schistosoma mansoni infection. J Egypt
Soc Parasitol. 2007 Apr;37(1):171-88. PubMed PMID: 17580576.

7: Meaney M, Allister J, McKinstry B, McLaughlin K, Brennan GP, Forbes AB,
Fairweather I. Fasciola hepatica: ultrastructural effects of a combination of
triclabendazole and clorsulon against mature fluke. Parasitol Res. 2007
Apr;100(5):1091-104. Epub 2006 Dec 19. PubMed PMID: 17180691.

8: Meaney M, Allister J, McKinstry B, McLaughlin K, Brennan GP, Forbes AB,
Fairweather I. Fasciola hepatica: morphological effects of a combination of
triclabendazole and clorsulon against mature fluke. Parasitol Res. 2006
Oct;99(5):609-21. Epub 2006 Aug 2. PubMed PMID: 16896655.

9: Meaney M, Haughey S, Brennan GP, Fairweather I. Ultrastructural observations
on oral ingestion and trans-tegumental uptake of clorsulon by the liver fluke,
Fasciola hepatica. Parasitol Res. 2005 Feb;95(3):201-12. Epub 2005 Jan 6. PubMed
PMID: 15645289.

10: Meaney M, Haughey S, Brennan GP, Fairweather I. A scanning electron
microscope study on the route of entry of clorsulon into the liver fluke,
Fasciola hepatica. Parasitol Res. 2005 Jan;95(2):117-28. Epub 2004 Dec 10.
Erratum in: Parasitol Res. 2005 Jun;96(3):189-98. PubMed PMID: 15592937.