For research use only. Not for therapeutic Use.
Clovoxamine, a nontricyclic antidepressant, has a dual action in blocking the reuptake of both noradrenaline and serotonin. Clovoxamine has little affinity for muscarinic, histaminergic, serotonergic and adrenergic binding sites. Clovoxamine induces a decrease in the functional beta-adrenergic receptor coupled c-AMP response.
| Catalog Number | I006170 |
| CAS Number | 54739-19-4 |
| Synonyms | Clovoxamine;(E)-1-(4-chlorophenyl)-5-methoxypentan-1-one O-(2-aminoethyl) oxime |
| Molecular Formula | C14H21ClN2O2 |
| Purity | ≥95% |
| Target | GPCR/G Protein |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| IUPAC Name | 2-[(E)-[1-(4-chlorophenyl)-5-methoxypentylidene]amino]oxyethanamine |
| InChI | InChI=1S/C14H21ClN2O2/c1-18-10-3-2-4-14(17-19-11-9-16)12-5-7-13(15)8-6-12/h5-8H,2-4,9-11,16H2,1H3/b17-14+ |
| InChIKey | XXPVSQRPGBUFKM-SAPNQHFASA-N |
| SMILES | COCCCCC(=NOCCN)C1=CC=C(C=C1)Cl |
| Reference | </br>1:Amitriptyline, clovoxamine and cognitive function: a placebo-controlled comparison in depressed outpatients. Spring B, Gelenberg AJ, Garvin R, Thompson S.Psychopharmacology (Berl). 1992;108(3):327-32. PMID: 1523282 </br>2:Clovoxamine in the treatment of depressed outpatients: a double-blind, parallel-group comparison against amitriptyline and placebo. Gelenberg AJ, Wojcik JD, Falk WE, Spring B, Brotman AW, Galvin-Nadeau M.Compr Psychiatry. 1990 Jul-Aug;31(4):307-14. PMID: 2201481 </br>3:Anxiety neurosis in general practice. A double-blind comparative study of diazepam and clovoxamine, a novel inhibitor of noradrenaline and serotonin reuptake. Jesinger DK, Gostick N.Int Clin Psychopharmacol. 1989 Oct;4(4):301-11. PMID: 2691573 </br>4:Effect of clovoxamine fumarate on the electrocardiogram. Goldie A, Edwards JG.J Psychopharmacol. 1989 Jan;3(1):29-31. doi: 10.1177/026988118900300105. PMID: 22156308 </br>5:Chronic treatment with fluvoxamine, clovoxamine, and placebo: interaction with digoxin and effects on sleep and alertness. Ochs HR, Greenblatt DJ, Verburg-Ochs B, Labedski L.J Clin Pharmacol. 1989 Jan;29(1):91-5. PMID: 2496149 </br>6:Biochemical effects in rats after acute and long-term treatment with clovoxamine. Bradford LD, Tulp MT, Schipper J.Arch Int Pharmacodyn Ther. 1987 Jun;287(2):188-202. PMID: 2820327 </br>7:Acute comparison of clovoxamine and mianserin, alone and in combination with ethanol, on human psychomotor performance. Strömberg C, Mattila MJ.Pharmacol Toxicol. 1987 May;60(5):374-9. PMID: 3615347 </br>8:Fluorimetric determination of fluvoxamine or clovoxamine in human plasma after thin-layer chromatographic or high-performance liquid chromatographic separation. Schweitzer C, Spahn H, Mutschler E.J Chromatogr. 1986 Oct 31;382:405-11. No abstract available. PMID: 3097046 </br>9:Clovoxamine and doxepin in major depressive disorder: a double-blind controlled trial. Lodge GJ, Freeman HL.Br J Psychiatry. 1986 Jun;148:718-21. PMID: 3535975 </br>10:[Action of clovoxamine on the sleep of depressed patients. /Polygraphic recordings/]. Minot R, Crocq MA, Roussel B, Marie-Cardine M.Encephale. 1985 Mar-Apr;11(2):65-70. French. PMID: 4017939 |
