Clozapine

• CAT Number: A000188
• CAS Number: 5786-21-0
• Molecular Formula: C18H19ClN4
• Molecular Weight: 326.8
• Purity: ≥95%
• Synonyms: 5786-21-0; Leponex; Clozapin; CLOZARIL; Fazaclo
• Target: Neuronal Signaling
• Solubility: >14.6mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
• InChIKey: ZUXABONWMNSFBN-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Clozapine is an atypical antipsychotic drug because it binds to serotonin as well as dopamine receptors. Clozapine is a partial agonist at the 5-HT1A subunit of the serotonin receptor, putatively improving depression, anxiety, and the negative cognitive symptoms associated with schizophrenia. A direct interaction of clozapine with the GABAB receptor has also been shown. GABAB receptor-deficient mice exhibit increased extracellular dopamine levels and altered locomotor behaviour equivalent to that in schizophrenia animal models.

Reference

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