Clozapine-d3

• CAT Number: R044243
• CAS Number: 1215691-72-7
• Molecular Formula: C18H19ClN4
• Molecular Weight: 329.846
• Purity: ≥95%
• Synonyms: 8-Chloro-11-[4-(methyl-d3)-1-piperazinyl]-5H-Dibenzo[b,e][1,4]diazepine; HF-1854,-d3; Liponex-d3
• Storage: 2°C to 8°C
• IUPAC Name: 3-chloro-6-[4-(trideuteriomethyl)piperazin-1-yl]-5H-benzo[b][1,4]benzodiazepine
• InChI: InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3/i1D3
• InChIKey: ZUXABONWMNSFBN-FIBGUPNXSA-N
• SMILES: CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Clozapine-d3 is a deuterated form of clozapine, an antipsychotic medication primarily used to treat schizophrenia. In this version, three hydrogen atoms are replaced with deuterium, enhancing its utility in pharmacokinetic and metabolic studies. The deuterium labeling allows for precise tracking and analysis in mass spectrometry and NMR spectroscopy, facilitating research into the drug’s absorption, distribution, metabolism, and excretion. Despite the isotopic modification, Clozapine-d3 retains the same therapeutic effects as the non-deuterated form, making it valuable for research into its pharmacological properties and safety.