For research use only. Not for therapeutic Use.
Clozapine-d8 (CAS: 1185053-50-2), a premium pharmaceutical research compound designed for advanced psychopharmacological and antipsychotic studies. As a deuterated analog of Clozapine, it offers enhanced stability and improved pharmacokinetic properties. Clozapine-d8 is ideal for use in pharmacological and biochemical research, providing precise and reliable data for your studies. This high-purity compound ensures consistent results, aiding in the development of novel therapies for schizophrenia and other psychiatric disorders. Trusted by leading laboratories, Clozapine-d8 is your go-to solution for cutting-edge mental health research. Unlock new possibilities in the treatment of psychiatric disorders with Clozapine-d8, where innovation meets reliability.
| Catalog Number | S000203 |
| CAS Number | 1185053-50-2 |
| Molecular Formula | C18H11D8ClN4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| IUPAC Name | 3-chloro-6-(2,2,3,3,5,5,6,6-octadeuterio-4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
| InChI | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3/i8D2,9D2,10D2,11D2 |
| InChIKey | QZUDBNBUXVUHMW-JNJBWJDISA-N |
| SMILES | [2H]C1(C(N(C(C(N1C)([2H])[2H])([2H])[2H])C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42)([2H])[2H])[2H] |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. [3]. Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40. [4]. Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26. [5]. Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2. |
