Clozapine N-oxide

• CAT Number: I003244
• CAS Number: 34233-69-7
• Molecular Formula: C18H19ClN4O
• Molecular Weight: 342.82
• Purity: ≥95%
• Synonyms: 3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-11H-benzo[b][1,4]benzodiazepine
• InChI: InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• InChIKey: OGUCZBIQSYYWEF-UHFFFAOYSA-N
• SMILES: C[N+]1(CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42)[O-]

Clozapine N-oxide (Cat No.:I003244) is a pharmacologically inert metabolite of clozapine, commonly used in neuroscience research as a ligand in chemogenetic studies, specifically with Designer Receptors Exclusively Activated by Designer Drugs (DREADDs). CNO selectively activates these engineered receptors, allowing precise control over neuronal activity and behavior in animal models. This tool is invaluable for investigating neural circuits, understanding brain function, and exploring potential treatments for neurological and psychiatric disorders. CNO’s specificity and efficacy in modulating DREADDs make it a critical component in advanced neurobiological research.