CLP-290

• CAT Number: I002860
• CAS Number: 1181083-81-7
• Molecular Formula: C19H21FN4O3S
• Molecular Weight: 404.46
• Purity: ≥95%
• Synonyms: [5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate
• Target: Potassium Channel
• Solubility: DMSO
• Storage: -20°C
• IUPAC Name: [2-[(Z)-[2-(diazinan-1-yl)-4-oxo-1,3-thiazol-5-ylidene]methyl]-5-fluorophenyl] pyrrolidine-1-carboxylate
• InChI: InChI=1S/C19H21FN4O3S/c20-14-6-5-13(15(12-14)27-19(26)23-8-3-4-9-23)11-16-17(25)22-18(28-16)24-10-2-1-7-21-24/h5-6,11-12,21H,1-4,7-10H2/b16-11-
• InChIKey: DIXMMXNNKLCLOM-WJDWOHSUSA-N
• SMILES: C1CCN(NC1)C2=NC(=O)C(=CC3=C(C=C(C=C3)F)OC(=O)N4CCCC4)S2

CLP-290 (CAT: I002860) is an innovative compound known for its modulation of KCC2 (K(+)-Cl(-) cotransporter isoform 2). It functions as a prodrug of CLP-257 and exhibits remarkable selectivity for KCC2 over closely related Cl- transporters. Through its unique mode of action, CLP-290 influences the activity of KCC2, which plays a pivotal role in regulating chloride ion transport. This modulation contributes to the control of neuronal excitability and the maintenance of inhibitory neurotransmission.