CLR-1502

• CAT Number: I025006
• CAS Number: 1255922-30-5
• Molecular Formula: C61H89ClN3O4P
• Molecular Weight: 994.82
• Purity: 98%
• Synonyms: CLR-1502; CLR 1502; CLR1502; GLOW2
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 18-((E)-6'-((E)-2-(1,3,3-trimethyl-3H-indol-1-ium-2-yl)vinyl)-2'-(2-((E)-1,3,3-trimethylindolin-2-ylidene)ethylidene)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-4-yl)octadecyl (2-(trimethylammonio)ethyl) phosphate chloride
• InChI: InChI=1S/C61H89N3O4P.ClH/c1-60(2)53-34-25-27-36-55(53)62(5)57(60)44-42-50-32-30-33-51(43-45-58-61(3,4)54-35-26-28-37-56(54)63(58)6)59(50)52-40-38-49(39-41-52)31-24-22-20-18-16-14-12-10-11-13-15-17-19-21-23-29-47-67-69(65,66)68-48-46-64(7,8)9;/h25-28,34-45H,10-24,29-33,46-48H2,1-9H3;1H/q+1;/p-1
• InChIKey: ABHSKOMCZVVTMW-UHFFFAOYSA-M
• SMILES: [Cl-].CN1C(=CC=C2/CCCC(=C2c3ccc(CCCCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C)cc3)C=CC4=[N+](C)c5ccccc5C4(C)C)C(C)(C)c6ccccc16

CLR-1502 is a tumor PET imaging agent.

Reference

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2. Korb ML, Warram JM, Grudzinski J, Weichert J, Jeffery J, Rosenthal EL. Breast cancer imaging using the near-infrared fluorescent agent, CLR1502. Mol Imaging. 2014;13. doi: 10.2310/7290.2014.00040. PMID: 25743270.
3. Deming DA, Maher ME, Leystra AA, Grudzinski JP, Clipson L, Albrecht DM, Washington MK, Matkowskyj KA, Hall LT, Lubner SJ, Weichert JP, Halberg RB. Phospholipid ether analogs for the detection of colorectal tumors. PLoS One. 2014 Oct 6;9(10):e109668. doi: 10.1371/journal.pone.0109668. PMID: 25286226; PMCID: PMC4186834.
4. Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS, Shusta EV. Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Mol Pharm. 2016 Sep 6;13(9):3341-9. doi: 10.1021/acs.molpharmaceut.6b00441. Epub 2016 Aug 4. PMID: 27421304; PMCID: PMC5014630.