CM-272

• CAT Number: I017270
• CAS Number: 1846570-31-7
• Molecular Formula: C₂₈H₃₈N₄O₃
• Molecular Weight: 478.63
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine
• InChI: InChI=1S/C28H38N4O3/c1-20-7-8-26(35-20)25-18-23(29-21-9-14-31(2)15-10-21)22-17-27(33-3)28(19-24(22)30-25)34-16-6-13-32-11-4-5-12-32/h7-8,17-19,21H,4-6,9-16H2,1-3H3,(H,29,30)
• InChIKey: RLQLKZTYUYIWDB-UHFFFAOYSA-N
• SMILES: CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5

CM-272（Cat No.:I017270）is a selective inhibitor of the histone methyltransferase EZH2, a key enzyme in the Polycomb repressive complex 2 (PRC2) that regulates gene expression through trimethylation of histone H3 at lysine 27 (H3K27me3). By targeting EZH2, CM-272 reactivates silenced tumor suppressor genes and disrupts oncogenic signaling pathways. This compound has shown significant anti-tumor effects in preclinical models, particularly in hematological malignancies and solid tumors with aberrant EZH2 activity. CM-272’s ability to modulate epigenetic regulation makes it a promising candidate for developing targeted therapies in cancer treatment.

Reference

[1]. San José-Enériz E, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies. Nat Commun. 2017 May 26;8:15424.