CM-4620

• CAT Number: I019966
• CAS Number: 1713240-67-5
• Molecular Formula: C₁₉H₁₁ClF₃N₃O₃
• Molecular Weight: 421.76
• Purity: ≥95%
• Target: CRAC Channel
• Storage: Store at -20°C
• IUPAC Name: N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)pyrazin-2-yl]-2-fluoro-6-methylbenzamide
• InChI: InChI=1S/C19H11ClF3N3O3/c1-9-3-2-4-12(21)17(9)18(27)26-16-8-24-13(7-25-16)10-5-14-15(6-11(10)20)29-19(22,23)28-14/h2-8H,1H3,(H,25,26,27)
• InChIKey: QQMKTHUGOQDEIL-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F

CM4620（Cat No.:I019966） is a selective inhibitor of calcium release-activated calcium (CRAC) channels, particularly targeting the ORAI1 channel. By inhibiting these channels, CM-4620 reduces calcium influx into cells, thereby modulating calcium-dependent signaling pathways involved in inflammation. This mechanism has been explored in conditions like acute pancreatitis, where excessive calcium influx contributes to disease pathology. Additionally, CM-4620 has been investigated for its potential benefits in treating severe COVID-19 pneumonia, aiming to mitigate infl