For research use only. Not for therapeutic Use.
CM037（Cat No.:I011303）is a selective inhibitor of Yes-associated protein (YAP), a key effector in the Hippo signaling pathway, which regulates cell proliferation, survival, and organ size. By targeting YAP activity, CM037 disrupts its interaction with transcriptional partners, thereby suppressing oncogenic gene expression linked to YAP overactivation. It exhibits anti-proliferative effects in cancer cells where YAP plays a critical role in tumorigenesis and chemoresistance. CM037 is a valuable research tool for studying Hippo pathway dynamics and holds potential for developing targeted therapies in YAP-driven cancers and regenerative medicine applications.
| CAS Number | 896795-60-1 |
| Synonyms | ethyl 2-[[4-oxo-3-(3-pyrrolidin-1-ylpropyl)-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]acetate |
| Molecular Formula | C21H25N3O3S2 |
| Purity | ≥95% |
| IUPAC Name | ethyl 2-[[4-oxo-3-(3-pyrrolidin-1-ylpropyl)-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]acetate |
| InChI | InChI=1S/C21H25N3O3S2/c1-2-27-17(25)14-28-21-22-18-15-8-3-4-9-16(15)29-19(18)20(26)24(21)13-7-12-23-10-5-6-11-23/h3-4,8-9H,2,5-7,10-14H2,1H3 |
| InChIKey | SKDRHRAYBYQVNU-UHFFFAOYSA-N |
| SMILES | CCOC(=O)CSC1=NC2=C(C(=O)N1CCCN3CCCC3)SC4=CC=CC=C42 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
