CMD178 TFA

• CAT Number: I046148
• Molecular Formula: C9H8F5KO3Y
• Molecular Weight: 964.05
• Purity: ≥95%
• InChI: InChI=1S/C7H8O.C2HF3O2.2FH.K.Y/c8-6-7-4-2-1-3-5-7;3-2(4,5)1(6)7;;;;/h1-5,8H,6H2;(H,6,7);2*1H
• InChIKey: QGZCHBCENMVUSJ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CO.C(=O)(C(F)(F)F)O.F.F.[K].[Y]

CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development[1].
CMD178 TFA (100 μM) suppresses IL-2-induced STAT5 phosphorylation and inhibits Foxp3 expression in T cells[1].
CMD178 TFA (100 μM) inhibits the development of Treg cells induced by IL2/sIL-2Rα signaling[1].

Reference

[1]. Price-Troska T, et, al. Inhibiting IL-2 signaling and the regulatory T-cell pathway using computationally designed peptides. Invest New Drugs. 2019 Feb;37(1):9-16.
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