For research use only. Not for therapeutic Use.
CMP5 is a selective PRMT5 inhibitor that blocked EBV-driven B-lymphocyte transformation and survival while leaving normal B cells unaffected. Also CMP5 inhibited Th1 cell proliferation (IC50 value 3.7 μM) more potently than Th2 cell proliferation (IC50 value 9.2 μM). In vivo, PRMT5 blockade efficiently suppressed recall T cell responses and reduced inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models.
Also the more potent and bioavailable derivative HLCL65 hydrochloride is available (Axon 2710).
KEYWORDS: CMP5 | supplier | PRMT5 inhibitor | CMP 5 | CMP-5 | CAS [1030021-40-9] | [880813-42-3] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes
| Catalog Number | I015414 |
| CAS Number | 1030021-40-9 |
| Molecular Formula | C20H22N3.HCl |
| Purity | ≥95% |
| IUPAC Name | 1-(9-ethylcarbazol-3-yl)-N-(pyridin-2-ylmethyl)methanamine;hydrochloride |
| InChI | InChI=1S/C21H21N3.ClH/c1-2-24-20-9-4-3-8-18(20)19-13-16(10-11-21(19)24)14-22-15-17-7-5-6-12-23-17;/h3-13,22H,2,14-15H2,1H3;1H |
| SMILES | CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=N3)C4=CC=CC=C41.Cl |
| Reference | L Alinari et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 2015 Apr 16;125(16):2530-43.
LM Webb et al. Protein Arginine Methyltransferase 5 (PRMT5) Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol 198 (4), 1439-1451. 2017 Jan 13. |
