CMPD-1

• CAT Number: I010520
• CAS Number: 41179-33-3
• Molecular Formula: C22H20FNO2
• Molecular Weight: 349.405
• Purity: ≥95%
• Synonyms: 2/’-Fluoro-N-(4-hydroxyphenyl)-[1,1/’-biphenyl]-4-butanamide
• Target: MAPKAPK2 (MK2)
• Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
• Storage: Store at RT
• IUPAC Name: 4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide
• InChI: InChI=1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)
• InChIKey: ODYAQBDIXCVKAE-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)CCCC(=O)NC3=CC=C(C=C3)O)F

CMPD-1 (CAT: I010520) is a non-ATP-competitive inhibitor that selectively targets the phosphorylation of MK2a (mitogen-activated protein kinase-2a) mediated by p38α. It exhibits an apparent Ki value of 330 nM for this inhibition. CMPD-1 does not inhibit p38α-mediated phosphorylation of MBP (myelin basic protein) and ATF-2 (activating transcription factor 2). Additionally, it acts as an inhibitor of tubulin polymerization. Notably, CMPD-1 demonstrates cytotoxic effects on glioblastoma cells at concentrations that do not affect the MK2 pathway.