CN128 hydrochloride

• CAT Number: I015513
• CAS Number: 1335282-05-7
• Molecular Formula: C15H18ClNO3
• Molecular Weight: 295.76
• Purity: ≥95%
• Synonyms: 3-hydroxy-1-[(2R)-1-hydroxy-3-phenylpropan-2-yl]-2-methylpyridin-4-one;hydrochloride
• InChI: InChI=1S/C15H17NO3.ClH/c1-11-15(19)14(18)7-8-16(11)13(10-17)9-12-5-3-2-4-6-12;/h2-8,13,17,19H,9-10H2,1H3;1H/t13-;/m1./s1
• InChIKey: CYFDKXLBMMEWNV-BTQNPOSSSA-N
• SMILES: CC1=C(C(=O)C=CN1C(CC2=CC=CC=C2)CO)O.Cl

CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia[1].
CN128 hydrochloride possesses a high selectivity for iron(III) over others metals[1].
CN128 hydrochloride (450 μmol/kg; p.o.) exhibits a good iron scavenging efficacy in rat[1].
The iron removal efficacies of CN128 displays a dose-dependent behavior[1].
CN128 hydrochloride lacks genetic toxicity[1].
CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].
CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats[1].

Reference

[1]. Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226.
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