For research use only. Not for therapeutic Use.
CNG-10300 is a partial blocker of GluK1, with GluK2 being unaffected.
| Catalog Number | I025044 |
| Synonyms | CNG10300; CNG 10300; CNG-10300 |
| Molecular Formula | C12H13N3O4 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-2-Amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid |
| InChI | InChI=1S/C12H13N3O4/c13-7(12(18)19)3-1-6-2-4-8-9(5-6)15-11(17)10(16)14-8/h2,4-5,7H,1,3,13H2,(H,14,16)(H,15,17)(H,18,19)/t7-/m0/s1 |
| InChIKey | HOBORVHHDCBXLX-ZETCQYMHSA-N |
| SMILES | O=C(O)[C@@H](N)CCC1=CC2=C(NC(C(N2)=O)=O)C=C1 |
| Reference | 1: Demmer CS, Møller C, Brown PM, Han L, Pickering DS, Nielsen B, Bowie D, Frydenvang K, Kastrup JS, Bunch L. Binding mode of an α-amino acid-linked quinoxaline-2,3-dione analogue at glutamate receptor subtype GluK1. ACS Chem Neurosci. 2015 Jun 17;6(6):845-54. doi: 10.1021/acschemneuro.5b00038. Epub 2015 Apr 9. PubMed PMID: 25856736. |
