For research use only. Not for therapeutic Use.
CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.
CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors[1]. CNT2 inhibitor-1 (compound 1) is a potent inhibitor with poor solubility[2].
| Catalog Number | I019752 |
| CAS Number | 880155-70-4 |
| Synonyms | (2R,3R,4S,5R)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Formula | C23H24N6O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H24N6O4/c24-20-17-21(27-12-26-20)29(22-19(32)18(31)16(11-30)33-22)23(28-17)25-10-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,12,16,18-19,22,30-32H,10-11H2,(H,25,28)(H2,24,26,27)/t16-,18-,19-,22-/m1/s1 |
| InChIKey | YJLIKUSWRSEPSM-WGQQHEPDSA-N |
| SMILES | C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=NC4=C(N=CN=C4N3C5C(C(C(O5)CO)O)O)N |
| Reference | [1]. Tatani K, et al. Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8. |
