CNX-011-67

• CAT Number: I006184
• Purity: ≥95%
• Synonyms: CNX-011-67; CNX011-67; CNX 011-67; CNX-01167; CNX01167; CNX 01167.;unknow.
• Target: GPR40 agonist
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term ,or -20 °C for long term

CNX-011-67（Cat No.:I006184）is a potent and selective small molecule agonist with an EC50 of 0.24 nM for human GPR40. It effectively suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro. Additionally, CNX-011-67 enhances glucose responsiveness, insulin secretion, and increases islet insulin content in n-STZ rats and islets derived from type 2 diabetic patients. Its targeted action on GPR40 holds potential for improving glucose homeostasis, offering a promising therapeutic approach for diabetes by modulating insulin secretion and glucagon levels under diabetic conditions.