For research use only. Not for therapeutic Use.
Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].
Co 101244 effectively reduces NMDA-evoked Ca2+ elevations while enhancing neuroprotection[1].
Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1].
| Catalog Number | I006185 |
| CAS Number | 193356-17-1 |
| Synonyms | 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]piperidin-4-ol;hydrochloride |
| Molecular Formula | C21H28ClNO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H27NO3.ClH/c1-17-2-4-18(5-3-17)16-21(24)10-12-22(13-11-21)14-15-25-20-8-6-19(23)7-9-20;/h2-9,23-24H,10-16H2,1H3;1H |
| InChIKey | WFFZHKKSIDENAJ-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)CC2(CCN(CC2)CCOC3=CC=C(C=C3)O)O.Cl |
| Reference | [1]. Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9. |
