For research use only. Not for therapeutic Use.
CO-102862 (CAT: I006186), also referred to as V102862, emerges as a potent and broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Its mechanism involves selectively affecting the conformational changes in these channels, thereby influencing their activity. This compound demonstrates robust anticonvulsant activity in diverse rodent models of epilepsy, making it a promising candidate for the treatment of seizure disorders.
| Catalog Number | I006186 |
| CAS Number | 181144-66-1 |
| Synonyms | CO-102862; CO 102862; CO102862; UNII-0KN11H90GF; V-102862.;2-((4-(4-Fluorophenoxy)phenyl)methylene)hydrazinecarboxamide |
| Molecular Formula | C14H12FN3O2 |
| Purity | ≥95% |
| Target | Sodium Channel |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at RT |
| Reference | </br>1:V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Ilyin VI, Hodges DD, Whittemore ER, Carter RB, Cai SX, Woodward RM.Br J Pharmacol. 2005 Mar;144(6):801-12. PMID: 15778702 Free PMC Article</br>2:Development of a high-performance liquid chromatographic-tandem mass spectrometric method for the determination of pharmacokinetics of Co 102862 in mouse, rat, monkey and dog plasma. Ramu K, Lam GN, Chien B.J Chromatogr B Biomed Sci Appl. 2000 Nov 10;749(1):1-15. PMID: 11129068 |
