For research use only. Not for therapeutic Use.
Coenzyme B<sub>12</sub> (adenosylcobalamin; AdoCbl) is a biologically active form of vitamin B<sub>12</sub> (Item No. <span class=/itemid/>18425</span>). It belongs to the corrinoid group of compounds, which contain a corrin macrocycle, and is produced only by certain bacteria and archaea. It is a cofactor for various enzymes including mutases, eliminases, aminomutases, and a reductase. These enzymes catalyze reactions that generate free radicals through release of the adenosyl group, allowing usually unreactive molecules to become reactive. Only one of these enzymes, methylmalonyl CoA mutase, is found in mammals, therefore, the other enzymes must be taken in through the diet. Genetic mutations in enzymes that synthesize AdoCbl lead to AdoCbl deficiency and methylmalonic aciduria. Formulations containing AdoCbl are used to treat patients with this disorder.
| Catalog Number | R023532 |
| CAS Number | 13870-90-1 |
| Synonyms | (5,6-Dimethylbenzimidazolyl)cobamide Coenzyme; (5’-Deoxy-5’-adenosyl)cobamide Coenzyme; 5,6-Dimethylbenzimidazolyl-Co-5’-deoxyadenosylcobamide; 5-Deoxyadenosylcobalamin; 5’-Deoxy-5’-adenosylcobalamin; 5’-Deoxyadenosyl Vitamin B12; 5’-Deoxyadenosyl-5, |
| Molecular Formula | C72H100CoN18O17P |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Storage | -20°C |
| InChIKey | OAJLVMGLJZXSGX-OUCXYWSSSA-L |
