Cocculine

• CAT Number: I025055
• CAS Number: 27675-39-4
• Molecular Formula: C17H21NO2
• Molecular Weight: 271.36
• Purity: 98%
• Synonyms: Cocculine; Sinomenine; Coculine
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (2S,13bS)-2-methoxy-2,3,5,6,8,9-hexahydro-1H-indolo[7a,1-a]isoquinolin-12-ol
• InChI: InChI=1S/C17H21NO2/c1-20-15-5-3-13-7-9-18-8-6-12-2-4-14(19)10-16(12)17(13,18)11-15/h2-4,10,15,19H,5-9,11H2,1H3/t15-,17-/m0/s1
• InChIKey: HJMBLPWMTXSDPK-RDJZCZTQSA-N
• SMILES: CO[C@H]1CC=C2CCN3[C@]2(C1)C4=C(CC3)C=CC(=C4)O

Cocculine（Cat No.:I025055）is a homeopathic remedy commonly used to alleviate symptoms of motion sickness, such as nausea, dizziness, and vomiting. It is a combination of highly diluted ingredients, including Cocculus indicus, a plant known for its ability to reduce nausea and balance disturbances caused by motion. Cocculine is believed to work by stimulating the body’s natural healing processes to restore equilibrium and improve tolerance to motion. It is often used by individuals who experience motion sickness while traveling or during other activities that induce vertigo or balance issues.

Reference

1: Retraction. Basic Clin Pharmacol Toxicol. 2020 Jun;126(6):498. doi: 10.1111/bcpt.13412. Epub 2020 Apr 23. PMID: 32410349.
2: Liu W, Zhang Y, Zhu W, Ma C, Ruan J, Long H, Wang Y. Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets. Front Immunol. 2018 Sep 26;9:2228. doi: 10.3389/fimmu.2018.02228. PMID: 30319663; PMCID: PMC6168735.
3: Retraction statement: Lipopolysaccharides-mediated injury to chondrogenic ATDC5 cells can be relieved by Sinomenine via downregulating microRNA-192. Phytother Res. 2020 Sep;34(9):2420. doi: 10.1002/ptr.6838. Epub 2020 Aug 7. PMID: 32959945.
4: Liu Z, Duan ZJ, Chang JY, Zhang ZF, Chu R, Li YL, Dai KH, Mo GQ, Chang QY; and the PLOS ONE Editors. Retraction: Sinomenine Sensitizes Multidrug-Resistant Colon Cancer Cells (Caco-2) to Doxorubicin by Downregulation of MDR-1 Expression. PLoS One. 2019 Apr 9;14(4):e0215388. doi: 10.1371/journal.pone.0215388. PMID: 30964927; PMCID: PMC6456210.
5: Zhu W, Zhang Y, Huang Y, Lu L. Chinese Herbal Medicine for the Treatment of Drug Addiction. Int Rev Neurobiol. 2017;135:279-295. doi: 10.1016/bs.irn.2017.02.013. Epub 2017 Mar 25. PMID: 28807162.
6: Liu S, Xu S, Wang Z, Guo Y, Pan W, Shen Z. Anti-Depressant-Like Effect of Sinomenine on Chronic Unpredictable Mild Stress-Induced Depression in a Mouse Model. Med Sci Monit. 2018 Oct 26;24:7646-7653. doi: 10.12659/MSM.908422. PMID: 30362468; PMCID: PMC6215386.
7: Pérol D, Provençal J, Hardy-Bessard AC, Coeffic D, Jacquin JP, Agostini C, Bachelot T, Guastalla JP, Pivot X, Martin JP, Bajard A, Ray-Coquard I. Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial. BMC Cancer. 2012 Dec 17;12:603. doi: 10.1186/1471-2407-12-603. PMID: 23244208; PMCID: PMC3582626.
8: Xu F, Li Q, Wang Z, Cao X. Sinomenine inhibits proliferation, migration, invasion and promotes apoptosis of prostate cancer cells by regulation of miR-23a. Biomed Pharmacother. 2019 Apr;112:108592. doi: 10.1016/j.biopha.2019.01.053. Epub 2019 Feb 18. PMID: 30784907.
9: Zheng XL, Jiang NF, Luo D, Gao HS, Ding AS. (7R,8S,9S,12S)-1-Benz- yloxy-13,14-didehydro-12-hy-droxy-2,13-dimeth-oxy-N-methyl-morphinane. Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2662-3. doi: 10.1107/S1600536811037226. Epub 2011 Sep 17. PMID: 22058779; PMCID: PMC3201304.
10: Zheng XL, Jiang NF, Gao HS, Luo D, Ding AS. (7R,8S,9S,12S)-1-(4-Chloro-benz- yloxy)-13,14-didehydro-12-hy-droxy-2,13-dimeth-oxy-N-methyl-morphinane. Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2480. doi: 10.1107/S160053681103443X. Epub 2011 Aug 27. PMID: 22059035; PMCID: PMC3200812.