Coenzyme A (sodium salt hydrate)

• CAT Number: R067016
• Molecular Formula: C21H35N7O16P3S • Na [H2O]
• Molecular Weight: 807.5
• Purity: ≥95%
• Synonyms: CoA
• Storage: -20°C
• InChI: InChI=1S/C21H36N7O16P3S.Na.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,
• InChIKey: SYTRWOCXZXQBPW-CLVRNSBASA-M
• SMILES: O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCS)=O)=O)(O)=O)(O)=O)[C@H]1OP([O-])(O)=O.[Na+].O

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid (Item No. 17288) in a five-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds.

Reference

1.Leonardi, R.,Zhang, Y.M.,Rock, C.O., et al. Coenzyme A: Back in action. Progress in Lipid Research 44(2-3), 125-153 (2005).