For research use only. Not for therapeutic Use.
Coenzyme FO（Cat No.:I015187）is a biochemical cofactor involved in microbial metabolic processes, particularly in methanogenic archaea. It plays a crucial role in the enzymatic pathway that aids in methane production by facilitating electron transfer reactions. Coenzyme FO is part of the larger F420 family of cofactors, known for its fluorescence under UV light, which makes it useful in studies tracking cellular metabolic activities. Due to its unique role in microbial energy metabolism, Coenzyme FO has become a research focus in understanding methane biogenesis, offering potential applications in biotechnology and environmental science.
| Catalog Number | I015187 |
| CAS Number | 37333-48-5 |
| Molecular Formula | C₁₆H₁₇N₃O₇ |
| Purity | ≥95% |
| Target | Anti-infection |
| IUPAC Name | 10-(2,3,4,5-tetrahydroxypentyl)-1H-pyrimido[4,5-b]quinoline-2,4,8-trione |
| InChI | InChI=1S/C16H17N3O7/c20-6-12(23)13(24)11(22)5-19-10-4-8(21)2-1-7(10)3-9-14(19)17-16(26)18-15(9)25/h1-4,11-13,20,22-24H,5-6H2,(H2,17,18,25,26) |
| InChIKey | HJMIIBXYFPJZBP-UHFFFAOYSA-N |
| SMILES | C1=CC(=O)C=C2C1=CC3=C(N2CC(C(C(CO)O)O)O)NC(=O)NC3=O |
| Reference | [1]. Mills DJ, et al. De novo modeling of the F(420)-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife. 2013;2:e00218. Published 2013 Mar 5.<br>[2]. Philmus B, et al. Biosynthetic versatility and coordinated action of 5′-deoxyadenosyl radicals in deazaflavin biosynthesis. J Am Chem Soc. 2015;137(16):5406-5413.<br>[3]. de Poorter LMI, et al. Hydrogen concentrations in methane-forming cells probed by the ratios of reduced and oxidized coenzyme F420. Microbiology. 2005;151(Pt 5):1697‐1705.<br>[4]. Purwantini E, et al. Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage. Proc Natl Acad Sci U S A. 2009;106(15):6333‐6338. |
