COG-1410

• CAT Number: I025061
• CAS Number: 878009-24-6
• Molecular Formula: C64H121N21O14
• Molecular Weight: 1408.8
• Purity: 98%
• Synonyms: COG-1410; COG 1410; COG1410
• Target: Apoptosis
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Store at -20°C
• IUPAC Name: (S)-6-amino-N-((S)-1-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)-2-((5S,8S,11S,14S,20S,23S)-8-(4-aminobutyl)-11-(3-guanidinopropyl)-20-(hydroxymethyl)-5,14-diisobutyl-2,2,17,17,23-pentamethyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazahexacosanamido)hexanamide
• InChI: InChI=1S/C64H121N21O14/c1-34(2)29-44(49(67)88)78-55(94)45(30-35(3)4)79-53(92)42(24-20-28-73-62(70)71)76-54(93)43(22-16-18-26-66)82-59(98)63(11,12)84-57(96)47(32-37(7)8)80-52(91)40(21-15-17-25-65)75-51(90)41(23-19-27-72-61(68)69)77-56(95)46(31-36(5)6)83-60(99)64(13,14)85-58(97)48(33-86)81-50(89)38(9)74-39(10)87/h34-38,40-48,86H,15-33,65-66H2,1-14H3,(H2,67,88)(H,74,87)(H,75,90)(H,76,93)(H,77,95)(H,78,94)(H,79,92)(H,80,91)(H,81,89)(H,82,98)(H,83,99)(H,84,96)(H,85,97)(H4,68,69,72)(H4,70,71,73)/t38-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1
• InChIKey: RPCLHYWMLWFFTE-VKTQGLPSSA-N
• SMILES: CC(C)C[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(C(C)(C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC(C(C)(C)NC([C@H](CO)NC([C@H](C)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

COG-1410（Cat No.:I025061） is a peptide mimetic of apolipoprotein E (apoE) that encompasses the amino acid sequence of the receptor-binding domain of apoE. It is designed to mimic the functional properties of apoE, a protein involved in lipid metabolism and neuronal repair. By resembling the receptor-binding domain, COG-1410 aims to exert therapeutic effects similar to apoE, potentially promoting neuronal regeneration and enhancing lipid metabolism.

Reference

1: Latypova EM, Timoshenko SI, Kislik GA, Vitek M, Shvartsman AL, Sarantseva SV. [Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster]. Biomed Khim. 2014 Jul-Aug;60(4):515-21. Russian. PubMed PMID: 25249536.