For research use only. Not for therapeutic Use.
COH000(CAT: I019600) is an allosteric, covalent, and irreversible inhibitor of the ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), a critical enzyme in the SUMOylation pathway. By targeting this enzyme, COH000 disrupts the activation of SUMO (Small Ubiquitin-like Modifier) proteins, inhibiting the downstream modification of substrate proteins. This mechanism makes it a valuable tool in ubiquitin and proteasome pathway research, particularly for studying protein homeostasis, signal transduction, and cellular stress responses. Its unique action provides insights into the role of SUMOylation in cancer, neurodegenerative diseases, and inflammation, supporting therapeutic development targeting SUMOylation dysregulation.
| Catalog Number | I019600 |
| CAS Number | 1534358-79-6 |
| Molecular Formula | C₂₅H₂₅NO₅ |
| Purity | ≥95% |
| Target | E1/E2/E3 Enzyme |
| IUPAC Name | dimethyl (1R,4S)-1-[(1R)-1-anilino-2-(4-methylphenyl)ethyl]-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate |
| InChI | InChI=1S/C25H25NO5/c1-16-9-11-17(12-10-16)15-20(26-18-7-5-4-6-8-18)25-14-13-19(31-25)21(23(27)29-2)22(25)24(28)30-3/h4-14,19-20,26H,15H2,1-3H3/t19-,20+,25-/m0/s1 |
| InChIKey | UFPINDDCTUCUSA-DFIYOIEZSA-N |
| SMILES | CC1=CC=C(C=C1)C[C@H]([C@]23C=C[C@H](O2)C(=C3C(=O)OC)C(=O)OC)NC4=CC=CC=C4 |
