For research use only. Not for therapeutic Use.
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro[1].<br>COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme[1].
| Catalog Number | I019600 |
| CAS Number | 1534358-79-6 |
| Molecular Formula | C₂₅H₂₅NO₅ |
| Purity | ≥95% |
| Target | E1/E2/E3 Enzyme |
| Reference | [1]. Li YJ, et al. Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme. Cell Chem Biol. 2018 Dec 5. pii: S2451-9456(18)30386-6. |
