COH34 analog 1

For research use only. Not for therapeutic Use.

  • CAT Number: I017885
  • CAS Number: 314248-24-3
  • Molecular Formula: C18H15NO3S
  • Molecular Weight: 325.38
  • Purity: ≥95%
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COH34 analog 1, a metabolite, is an oxidized analog of COH34. COH34 is a potent poly(ADP-ribose) glycohydrolase (PARG) inhibitor[1].


Catalog Number I017885
CAS Number 314248-24-3
Synonyms

(NE)-N-[(2-hydroxynaphthalen-1-yl)methylidene]-4-methylbenzenesulfonamide

Molecular Formula C18H15NO3S
Purity ≥95%
InChI InChI=1S/C18H15NO3S/c1-13-6-9-15(10-7-13)23(21,22)19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+
InChIKey WCYGPLQLYOSVIH-XDHOZWIPSA-N
SMILES CC1=CC=C(C=C1)S(=O)(=O)N=CC2=C(C=CC3=CC=CC=C32)O
Reference

[1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.
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